A limitation of relying entirely on genomic data to determine a therapeutic strategy is that it ignores functionally-related, non-mutated genes that could also encode potential drug targets. While DNA sequencing has enabled a comprehensive characterization of tumor genomes and stratification of patients, translating such information into treatment strategies has remained a major challenge. We generated an mTOR-driven HCC mouse model, by liver-specific deletion of the tumor suppressors Pten and Tsc1, to investigate the molecular and cellular mechanisms of mTOR-driven tumorgenicity. However, the effector pathways via which mTOR promotes tumorgenicity are widely unknown. Approximately 50% of HCC tumors exhibit loss of the tumor suppressors Pten, Tsc1, or Tsc2 leading to aberrant PI3K–AKT–mTOR signaling. Garmin Messaging Garmin Messaging will allow you to communicate with your drivers and upload new destinations directly through Silent Passenger using a Garmin navigation unit mounted in the vehicle.Liver cancer is the second leading cause of cancer-related deaths worldwide, and hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer cases. Plus, Microsoft’s annual map upgrades ensure you have the most up-to-date maps available. ![]() Bing Maps is an industry leader in providing precise views of the world through bird’s eye view and panning, and photorealistic and geospecific 3d capability, among other features. Microsoft Bing Maps The Microsoft Bing Maps platform provides the very best in mapping. Send those directions directly to your drivers’ cell or use the Garmin Messaging feature for in-vehicle navigation. Turn-By-Turn Driving Directions Silent Passenger enables users to plot and print driving directions on detailed maps. ![]() stay ahead of the game by knowing about congestion, bottle-necking and road closures before you send your trucks out. Real-Time Traffic Updates Real-time traffic updates will allow your dispatchers to make effective and efficient decisions when routing your company vehicles. Use this feature to see when your vehicles exceed posted speed limits. SpeedGauge True Speed Notification System The industry’s first and only true speed notification system is available in Silent Passenger. you can even set up automatic email reports to alert you on a daily, weekly or monthly basis of upcoming maintenance issues. Vehicle Maintenance Module The vehicle maintenance program in Silent Passenger allows you to monitor oil changes, inspections and other routine vehicle maintenance. Users are also able to create landmarks for customer locations, employee addresses and any other frequently visited address. Geofencing And Landmarks Silent Passenger users are able to set a radius and be notified when vehicles enter or exit that area with the geofencing tool. ![]() Have text alerts sent to your cell phone when a driver starts his day, exceeds speed limits, enters an unauthorized area or for vehicle use during off hours. Have all the information you need delivered straight to your inbox!Įxception-Based Text Notifications When you need information right away, use our text notification system. ![]() Choose any of our fully customizable reports to be emailed to you on a daily, weekly or monthly basis. You may view up to 13 months of historical reports at any time.Īutomatic Email Reports With our automatic email reports, you never have to take the time to run a report again. Generate fully customizable reports based on your informational needs and access them at your convenience. No software to install, no restrictions to worry about.įully Customizable Reports Our easy-to-use reporting system makes it simple to track your fleet on your own time. Silent Passenger integrates detailed, up-to-date maps from Microsoft Bing with real-time traffic information and turn-by-turn directions.īecause Silent Passenger is a web-based solution, you have the convenience and mobility of working from any computer, anywhere. Silent Passenger is a cutting-edge fleet management program that makes it easy to effectively and efficiently monitor your vehicles. Silent Passenger Sets The Standard For Fleet Management Software.
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